On the Non-Gaussianity Observed in the COBE-DMR Sky Maps

In this paper we pursue the origin of the non-Gaussianity determined by a bispectrum analysis of the COBE-DMR 4-year sky maps. The robustness of the statistic is demonstrated by the rebinning of the data into 12 coordinate systems. By computing the bispectrum statistic as a function of various data partitions - by channel, frequency, and time interval, we show that the observed non-Gaussian signal is driven by the 53 GHz data. This frequency dependence strongly rejects the hypothesis that the signal is cosmological in origin. A jack-knife analysis of the coadded 53 and 90 GHz sky maps reveals those sky pixels to which the bispectrum statistic is particularly sensitive. We find that by removing data from the 53 GHz sky maps for periods of time during which a known systematic effect perturbs the 31 GHz channels, the amplitudes of the bispectrum coefficients become completely consistent with that expected for a Gaussian sky. We conclude that the non-Gaussian signal detected by the normalised bispectrum statistic in the publicly available DMR sky maps is due to a systematic artifact. The impact of removing the affected data on estimates of the normalisation of simple models of cosmological anisotropy is negligible.Comment: 14 pages, plus 8 Postscript and 3 GIF figures. LaTeX2e document using AASTeX v5.0 macros. Revised version accepted for publication in the Astrophysical Journal: small changes to the text, minor modifications to figures 1 and

Formality and informality in the summative assessment of motor vehicle apprentices: a case study

This article explores the interaction of formal and informal attributes of competence‐based assessment. Specifically, it presents evidence from a small qualitative case study of summative assessment practices for competence‐based qualifications within apprenticeships in the motor industry in England. The data are analysed through applying an adaptation of a framework for exploring the interplay of formality and informality in learning. This analysis reveals informal mentoring as a significant element which influences not only the process of assessment, but also its outcomes. We offer different possible interpretations of the data and their analysis, and conclude that, whichever interpretation is adopted, there appears to be a need for greater capacity‐building for assessors at a local level. This could acknowledge a more holistic role for assessors; recognise the importance of assessors’ informal practices in the formal retention and achievement of apprentices; and enhance awareness of inequalities that may be reinforced by both informal and formal attributes of assessment practices

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

Sirtuin-1 (SIRT1) and SIRT6, NAD(+)-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of the lung and associated with increased oxidative stress. Here, we show that oxidative stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not the related miR-34b/c, with concomitant reduction of SIRT1/-6 in bronchial epithelial cells (BEAS2B), which was also observed in peripheral lung samples from patients with COPD. Over-expression of a miR-34a mimic caused a significant reduction in both mRNA and protein of SIRT1/-6, whereas inhibition of miR-34a (antagomir) increased these sirtuins. Induction of miR-34a expression with H2O2 was phosphoinositide-3-kinase (PI3K) dependent as it was associated with PI3Kα activation as well as phosphatase and tensin homolog (PTEN) reduction. Importantly, miR-34a antagomirs increased SIRT1/-6 mRNA levels, whilst decreasing markers of cellular senescence in airway epithelial cells from COPD patients, suggesting that this process is reversible. Other sirtuin isoforms were not affected by miR-34a. Our data indicate that miR-34a is induced by oxidative stress via PI3K signaling, and orchestrates ageing responses under oxidative stress, therefore highlighting miR-34a as a new therapeutic target and biomarker in COPD and other oxidative stress-driven aging diseases

Challenges to enabling and implementing Natural Flood Management in Scotland

The research for this paper was supported by the Scottish Government RESAS Strategic Research Programme 2011–2016.We explore factors that constrain implementation of Natural Flood Management (NFM), based on qualitative analysis of interviews with those influencing and enabling flood risk management in Scotland. NFM entails collaboration by multiple individuals and organisations to plan and deliver measures such as re-meandering or buffer strips. Our interviewees identified many interacting issues. They particularly focused on difficulties in securing resources, and evidence gaps and uncertainties associated with NFM. Co-ordination was not simple, often requiring new types of skill, expertise, and resources. NFM is thus outside the ‘comfort zone’ of many leading or engaged with flood risk management. These experiences echo and elaborate on other studies of attempts to encourage sustainable flood management. To tackle these challenges, practitioners should reflect how pre-existing ideas and practices may shape and constrain new approaches to managing floods, while research is needed on specific strategies that can assist in enabling change.Publisher PDFPeer reviewe

Collaboration and contestation in further and higher education partnerships in England: a Bourdieusian field analysis

Internationally, ‘College for All’ policies are creating new forms of vocational higher education (HE), and shifting relationships between HE and further education (FE) institutions. In this paper, we consider the way in which this is being implemented in England, drawing on a detailed qualitative case study of a regional HE–FE partnership to widen participation. We focus on the complex mix of collaboration and contestation that arose within it, and how these affected socially differentiated groups of students following high- and low-status routes through its provision. We outline Bourdieu’s concept of ‘field’ as a framework for our analysis and interpretation, including its theoretical ambiguities regarding the definition and scale of fields. Through hermeneutic dialogue between data and theory, we tentatively suggest that such partnerships represent bridges between HE and FE. These bridges are strong between higher-status institutions, but highly contested between lower-status institutions competing closely for distinction. We conclude that the trajectories and outcomes for socially disadvantaged students require attention and collective action to address the inequalities they face, and that our theoretical approach may have wider international relevance beyond the English case

A Review and Recommendations for Assessing Floodplain Vegetation Recovery Following Stage 0 and Beaver Dam Analog Restorations in the Pacific Northwest

Floodplains are a significant and increasingly threatened ecosystem. As restoration projects are implemented more frequently in degraded floodplains, novel methods are emerging with a focus on restoring critical processes in which vegetation plays a key role. The purpose of this paper is two-fold: 1) to develop expectations for vegetation response, and 2) to provide recommendations for implementation and monitoring of emerging restoration methods that fit within both the ecological and social frameworks of the landscape. First, I conduct a review of vegetation recovery following dam removal and floodplain reconnection to provide an assessment of potential vegetation responses and riparian plant community development for two novel types of stream restoration that are emerging as potentially valuable techniques, but which have limited data on vegetation recovery: Stage 0 restoration and beaver dam analogs (BDAs). Second, I provide recommendations for implementing restoration monitoring of vegetation for these two emerging restoration methods that are derived from this review. Because these restoration methods are new, there is a dearth of empirical data on these specific actions, but a review of the literature from related stream restorations provides insight into what may be expected. Further, restoration is often conducted with a focus on the physical and biological dynamics of the system with little regard for the social dynamics, yet the implementation and evaluation of restoration social frameworks can be as important as ecological frameworks. Therefore, I include social as well as biophysical factors in evaluating and making recommendations for vegetation assessment in these novel types of restoration. Focusing specifically on floodplains in small river systems in the Pacific Northwest (PNW), I address vegetation disturbance responses, natural recruitment of forbs and shrubs, nonnative vegetation, replanting efforts, and sociocultural considerations. In developing expectations for vegetation responses, the objectives of the paper are to explore the questions: 1) What do we expect to see in terms of plant community development following Stage 0 restoration and beaver dam analogs, 2) how does this affect recommendations for how floodplain restorations with these treatments are managed, and 3) how do these recommendations fit within the social context of the landscape? These questions were addressed through a review of the fairly limited literature on Stage 0 restoration and beaver dam analogs and the development of a conceptual framework based on a systematic review of dam removal and floodplain reconnection studies. In doing so, 6 key recommendations were identified. These include: 1) Restoration should be placed in a disturbance framework, 2) Restoration should be placed within the social framework of the system both locally and at a landscape scale, 3) Restoration should include more research in order to understand variability across systems, 4) standardization of metrics and tools for evaluating vegetation response, 5) Restoration should include more vegetation monitoring and consideration of long-term processes, 6) Restoration should include active revegetation and facilitation of natural recruitment

Study and implementation of urogenital schistosomiasis elimination in Zanzibar (Unguja and Pemba islands) using an integrated multidisciplinary approach

ABSTRACT: BACKGROUND: Schistosomiasis is a parasitic infection that continues to be a major public health problem in many developing countries being responsible for an estimated burden of at least 1.4 million disability-adjusted life years (DALYs) in Africa alone. However, morbidity due to schistosomiasis has been greatly reduced in some parts of the world, including Zanzibar. The Zanzibar government is now committed to eliminate urogenital schistosomiasis. Over the next 3--5 years, the whole at-risk population will be administered praziquantel (40 mg/kg) biannually. Additionally, snail control and behaviour change interventions will be implemented in selected communities and the impact measured in a randomized intervention trial. METHODS: In this 5-year research study, on both Unguja and Pemba islands, urogenital schistosomiasis will be assessed in 45 communities with urine filtration and reagent strips in 4,500 schoolchildren aged 9--12 years annually, and in 4,500 first-year schoolchildren and 2,250 adults in years 1 and 5. Additionally, from first-year schoolchildren, a finger-prick blood sample will be collected and examined for Schistosoma haematobium infection biomarkers. Changes in prevalence and infection intensity will be assessed annually. Among the 45 communities, 15 were randomized for biannual snail control with niclosamide, in concordance with preventive chemotherapy campaigns. The reduction of Bulinus globosus snail populations and S. haematobium-infected snails will be investigated. In 15 other communities, interventions triggering behaviour change have been designed and will be implemented in collaboration with the community. A change in knowledge, attitudes and practices will be assessed annually through focus group discussions and in-depth interviews with schoolchildren, teachers, parents and community leaders. In all 45 communities, changes in the health system, water and sanitation infrastructure will be annually tracked by standardized questionnaire-interviews with community leaders. Additional issues potentially impacting on study outcomes and all incurring costs will be monitored and recorded. DISCUSSION: Elimination of schistosomiasis has become a priority on the agenda of the Zanzibar government and the international community. Our study will contribute to identifying what, in addition to preventive chemotherapy, needs to be done to prevent, control, and ultimately eliminate schistosomiasis, and to draw lessons for current and future schistosomiasis elimination programmes in Africa and elsewhere.Trial registrationISRCTN4883768

Interpreting ambiguous ‘trace’ results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard

Background The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very sensitive at low infection intensities. A point-of-care circulating cathodic antigen (CCA) test has been shown to be more sensitive than KK. However, CCA can return an ambiguous ‘trace’ result between ‘positive’ and ‘negative’, and much debate has focused on interpretation of traces results. Methodology/Principle findings We show how LCA can be extended to include ambiguous trace results and analyse S. mansoni studies from both Côte d’Ivoire (CdI) and Uganda. We compare the diagnostic performance of KK and CCA and the observed results by each test to the estimated infection prevalence in the population. Prevalence by KK was higher in CdI (13.4%) than in Uganda (6.1%), but prevalence by CCA was similar between countries, both when trace was assumed to be negative (CCAtn: 11.7% in CdI and 9.7% in Uganda) and positive (CCAtp: 20.1% in CdI and 22.5% in Uganda). The estimated sensitivity of CCA was more consistent between countries than the estimated sensitivity of KK, and estimated infection prevalence did not significantly differ between CdI (20.5%) and Uganda (19.1%). The prevalence by CCA with trace as positive did not differ significantly from estimates of infection prevalence in either country, whereas both KK and CCA with trace as negative significantly underestimated infection prevalence in both countries. Conclusions Incorporation of ambiguous results into an LCA enables the effect of different treatment thresholds to be directly assessed and is applicable in many fields. Our results showed that CCA with trace as positive most accurately estimated infection prevalence

The Topology of Large Scale Structure in the 1.2 Jy IRAS Redshift Survey

We measure the topology (genus) of isodensity contour surfaces in volume limited subsets of the 1.2 Jy IRAS redshift survey, for smoothing scales \lambda=4\hmpc, 7\hmpc, and 12\hmpc. At 12\hmpc, the observed genus curve has a symmetric form similar to that predicted for a Gaussian random field. At the shorter smoothing lengths, the observed genus curve shows a modest shift in the direction of an isolated cluster or ``meatball'' topology. We use mock catalogs drawn from cosmological N-body simulations to investigate the systematic biases that affect topology measurements in samples of this size and to determine the full covariance matrix of the expected random errors. We incorporate the error correlations into our evaluations of theoretical models, obtaining both frequentist assessments of absolute goodness-of-fit and Bayesian assessments of models' relative likelihoods. We compare the observed topology of the 1.2 Jy survey to the predictions of dynamically evolved, unbiased, gravitational instability models that have Gaussian initial conditions. The model with an $n=-1$, power-law initial power spectrum achieves the best overall agreement with the data, though models with a low-density cold dark matter power spectrum and an $n=0$ power-law spectrum are also consistent. The observed topology is inconsistent with an initially Gaussian model that has $n=-2$, and it is strongly inconsistent with a Voronoi foam model, which has a non-Gaussian, bubble topology.Comment: ApJ submitted, 39 pages, LaTeX(aasms4), 12 figures, 1 Tabl